Engineering an allosteric transcription factor to respond to new ligands

Noah D Taylor,Alexander S Garruss,Rocco Moretti,Sum Chan,Mark A Arbing,Duilio Cascio,Jameson K Rogers,Farren J Isaacs,Sriram Kosuri,David Baker,Stanley Fields,George M Church,Srivatsan Raman

NATURE METHODS（2015）

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摘要

The combination of computational protein design and single-site saturation mutagenesis enables engineering of allosteric transcription factors to respond to new small molecules.

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