Oxidation Studies On Beta-Lactam Antibiotics - Invitro Antimicrobial Activity Of The Oxidized Products Of 3-Heteroarylthiomethyl-Ceph-3-Ems
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS(1991)
摘要
Various products from the oxidation of 3-heteroarylthiomethyl-ceph-3-ems using m-chloroperbenzoic acid (m-CPBA) and hydrogen peroxide in acetic acid in varying stoichiometric ratios have been isolated, identified and their in vitro antimicrobial activity determined. The oxidized compounds with the 2-aminothiazol-4-yl-(Z)-2-methoxyiminoacetamido side chain showed better antibacterial activity against various Gram negative bacteria compared to the unoxidized compounds.
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关键词
antimicrobial activity,antibiotics,oxidation,in-vitro,heteroarylthiomethyl-ceph
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