Adiponectin Rescues Lipotoxic Cardiomyopathy By Promoting Sphingosine-1-Phosphate And Ceramidase Expression

Geoffrey Weiting Cho, Yukiko Miyauchi,Joshua Johnson,William L. Holland,Joseph Hill

Journal of the American College of Cardiology（2015）

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摘要

Hyperlipidemia and ceramide accumulation are significant factors in cardiovascular disease, contributing to atherosclerosis and lipotoxic cardiomyopathy. The adipose-derived circulating factor adiponectin, as well as sphingosine 1-phosphate (S1P), may function to limit the harmful effects of ectopic

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