DIRECT TRANSDIFFERENTIATION OF HUMAN AMNIOTIC MESENCHYMAL STEM CELLS INTO CARDIAC PROGENITOR-LIKE CELLS

Phillip Yang,Rajesh Dash,Paul Kim,Xiaohu Ge,Yuka Matsuura

Journal of the American College of Cardiology（2013）

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摘要

Epigenetic reprogramming by valproic acid (VPA) induces intermediate pluripotency in human amniotic mesenchymal stem cells (hAMSCs). The hAMSCs dedifferentiate into precardiac mesoderms to undergo direct transdifferentiation into cardiac progenitor-like cells, using Wnt-pathway specific small

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