CARDIAC MYOSIN-BINDING PROTEIN C PHOSPHORYLATION ENHANCES CARDIAC RELAXATION

D Mukhopadhyay,Yang Liu,Mohamed Abdalla,Himakarnika Alluri,Candice M Thomas,Rajesh Kumar,Chad M Warren,Patricia A Powers,Kenneth M Baker,Richard L Moss,R John Solaro,Carl Tong

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2013）

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摘要

Cardiac myosin-binding protein-C (MyBPC3), a thick filament protein that inhibits myosin-actin interaction to slow cross-bridge cycling, has been implicated in diastolic dysfunction. MyBPC3 phosphorylation releases this inhibition; thus, we hypothesize that MyBPC3 phosphorylation promotes lusitropy

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关键词

phosphorylation,relaxation,myosin-binding

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