Highly Diastereoselective Synthesis Of Cyclopentenones Via A One-Pot Gold Catalysis, Nazarov Cyclization And Alkylation Cascade

Starting from readily available propargylic carboxylates, three sequential transformations [gold-catalyzed tandem reaction, scandium(III) trifluoromethanesulfonate catalyzed Nazarov cyclization, alkylation reaction] in a one-pot process led to the formation of cyclopentenone derivatives in excellent diastereoselectivities and moderate to good overall yields.