COX-2 inhibition attenuates lung injury induced by skeletal muscle ischemia reperfusion in rats

Liangrong Wang,Yuanlu Shan,Yuzhu Ye,Lida Jin,Qian Zhuo,Xiangqing Xiong,Xiyue Zhao,Lina Lin,Jianxia Miao

International Immunopharmacology（2016）

引用 14|浏览4

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摘要

•Pulmonary COX-2 protein is upregulated in response to limb ischemia reperfusion.•AQP-1 downregulation contributes to lung injury after limb ischemia reperfusion.•COX-2 inhibition mitigates lung injury after limb ischemia reperfusion.

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关键词

Cyclooxygenase,Aquaporin,Reperfusion injury,Skeletal muscle,Lung injury

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