A computational approach inspired by simulated annealing to study the stability of protein interaction networks in cancer and neurological disorders

    Data Mining and Knowledge Discovery, Volume 30, Issue 1, 2015.

    Cited by: 5|Bibtex|Views19|Links
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    Keywords:
    Simulated annealingSystems biologyGene expressionProtein interaction networksCancerMore(2+)

    Abstract:

    Molecular networks provide a powerful tool for the study of biomedical systems, in particular several studies have detected alterations of the network structure associated to disease states. Here we propose that diseases cannot only alter the structure of the network but also its stability. To evaluate network stability we have developed ...More

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