Genomic Characterization of Upper Tract Urothelial Carcinoma

European Urology（2016）

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摘要

We performed next-generation sequencing of 83 upper tract urothelial carcinoma (UTUC) tumors to characterize the landscape of genomic alterations. Comparison with high-grade bladder cancer identified more frequent FGFR3, HRAS, and CDKN2B alterations and fewer TP53 and RB1 mutations in high-grade UTUC.

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关键词

Upper tract urothelial carcinoma,Genomics,Bladder cancer,Targeted therapy

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