ACUTE APPENDICITIS WITH GENERALIZED PERITONITIS: TREATED BY INTRAVENOUS AND DIRECT INTRAPERITONEAL INJECTION OF A SULFONAMIDE DERIVATIVE

The use of sulfonamide derivatives in the treatment of peritonitis of appendical origin was first reported in 1939 by Corry, Brewer and Nicol. 1 Further studies were made by Ravdin, Rhoads and Lockwood 2 and Michel. 3 These authors, administering the drug intravenously, reported striking improvement in the mortality and morbidity of this disease in their series of cases. In 1941 Thompson, Brabson and Walker 4 suggested that the drug be introduced directly into the abdominal cavity at the time of operation. Rea 5 concluded that the sulfonamides are most effective when introduced directly into the peritoneal cavity. REPORT OF CASE B. P., a Negro child aged 2½ years, was admitted to the surgical service of Sydenham Hospital on July 25, 1941 with a four day history of vomiting, abdominal pains and constipation. Prior to hospitalization the child had been treated with cathartics and enemas. On the first examination the