Circulatory response to volume expansion and transjugular intrahepatic portosystemic shunt in refractory ascites: Relationship with diastolic dysfunction

Background: Cirrhotic cardiomyopathy may lead to heart failure in stressful circumstances, such as after transjugular intrahepatic portosystemic shunt (TIPS) placement. Aim: To examine whether acute volume expansion predicts haemodynamic changes after TIPS and elicits signs of impending heart failure. Methods: We prospectively evaluated refractory ascites patients (group A) and compensated cirrhotics (group B), who underwent echocardiography, NT-proBNP measurement, and heart catheterization before and after volume load; group A repeated measurements after TIPS. Results: 15 patients in group A (80% male; 54 +/- 12.4 years) and 8 in group B (100% male; 56 +/- 6.2 years) were enrolled. Echocardiography disclosed diastolic dysfunction in 30% and 12.5%, respectively. In group A, volume load and TIPS induced a significant increase in right atrial, mean pulmonary, capillary wedge pressure and cardiac index, and a decrease in systemic vascular resistance (respectively, 4.7 +/- 2.8 vs. 9.9 +/- 3.6 mmHg; 13.3 +/- 3.5 vs. 21.9 +/- 5.9 mmHg; 8.3 +/- 3.4 vs. 15.4 +/- 4.7 mmHg; 3.7 +/- 0.7 vs. 4.6 +/- 1 lt/min/m(2); 961 +/- 278 vs. 767 +/- 285 dyn s cm(-5); and 10.1 +/- 3.3 vs. 14.2 +/- 3.4 mmHg; 17.5 +/- 4 vs. 25.2 +/- 4.2 mmHg; 12.3 +/- 4 vs. 19.3 +/- 3.4 mmHg; 3.4 +/- 0.8 vs. 4.5 +/- 0.91 lt/min/m(2); 779 +/- 62 vs. 596 +/- 199 dyn s cm(-5), p < 0.001 for all pairs). At 24 h, cardiopulmonary pressures returned towards baseline. Conclusions: Acute volume expansion predicted haemodynamic changes immediately after TIPS. All patients had adequate haemodynamic adaptation to TIPS; none developed signs of heart failure. (c) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.