Predictive biomarkers of preterm delivery in women with ongoing IVF pregnancies

Tomi T Kanninen,Giovanni Sisti,Ilana Ramer,Dan Goldschlag,Steven S Witkin,S D Spandorfer

Journal of Reproductive Immunology（2015）

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摘要

•Sera from IVF patients who delivered preterm or at term were evaluated.•HE4 (p<0.000) and IL-13 (p=0.001) were reduced in women with a preterm birth.•IGF-II (p=0.023) and SLPI (p=0.043) were increased in women with a preterm birth.•The combination of HE4 and IL-13 were the best predictors of pregnancy outcome.

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关键词

IVF,PTD,HE4,SLPI,IGF-I,IGF-II,IGFBP-1,IVF-ET,E2,HMG,FSH,HCG,AUC,ROC,ICSI

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