Changes in inflammatory mediators in gingival crevicular fluid following periodontal disease treatment in pregnancy: relationship to adverse pregnancy outcome

•Treating periodontal disease in pregnancy improved clinical periodontal parameters.•Treatment also reduced inflammation in GC fluid, as judged by lower cytokine levels.•Not all cytokines were decreased: TNF-α and MCP1 levels increased with treatment.•Periodontal disease severity was associated with an increased risk of SGA deliveries.