Is the preoperative urinary prostate cancer gene 3 (PCA3) score's associated with Gleason score dependent tumor volume and Gleason pattern specific tumor volume?

You have accessJournal of UrologyProstate Cancer: Markers II1 Apr 20122231 IS THE PREOPERATIVE URINARY PROSTATE CANCER GENE 3 (PCA3) SCORE'S ASSOCIATED WITH GLEASON SCORE DEPENDENT TUMOUR VOLUME AND GLEASON PATTERN SPECIFIC TUMOUR VOLUME? Marco Auprich, Sebastian Mannweiler, Felix K.H. Chun, Katrin Mayrhofer, Alexander Haese, John F. Ward, Richard Babaian, Karl Pummer, and Herbert Augustin Marco AuprichMarco Auprich Graz, Austria More articles by this author , Sebastian MannweilerSebastian Mannweiler Graz, Austria More articles by this author , Felix K.H. ChunFelix K.H. Chun Hamburg, Germany More articles by this author , Katrin MayrhoferKatrin Mayrhofer Graz, Austria More articles by this author , Alexander HaeseAlexander Haese Hamburg, Germany More articles by this author , John F. WardJohn F. Ward Houston, TX More articles by this author , Richard BabaianRichard Babaian Houston, TX More articles by this author , Karl PummerKarl Pummer Graz, Austria More articles by this author , and Herbert AugustinHerbert Augustin Graz, Austria More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2407AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In a recent study, the association of the pre-operative urinary Prostate CAncer Gene 3 (PCA3) score with pathologically derived tumour volume in dependency of Gleason score was discussed. Therefore we evaluated if the PCA3 score correlates to Gleason score, Gleason score dependent tumour volume (TV) and Gleason pattern specific tumour volume. METHODS Complete retrospective clinical and pathological data of consecutive RP men from three referral centres including pre-operative urinary PCA3 scores and computer-assisted planimetrically derived TV data were available in 287 patients, whereas in 127 of these Gleason pattern specific TV was separately measured. High grade cancer was defined as PCa presenting Gleason pattern 4 and 5. PCA3 scores were assessed preoperatively using the Progensa® assay. Spearman's rank correlations coefficients (rs) were calculated to asses if the PCA3 score correlates with 1.) Gleason score (GS) 2.) Gleason score dependent tumour volume (GDTV), and 3.) Gleason pattern specific tumour volume (GPTV). RESULTS Overall median PSA, PCA3 score, GS, TV and primary and secondary GL pattern TV (ml) were 5,90ng/ml (0.62–73.0), 48 (2–289), 7 (4–10), 2.26ml (0.01–19.61) and 2.86ml (0.2–19.61) and 1.33 ml (0.3–3.76). Moreover 193 out of 287 (67.2%) patients presented with high grade PCa in detail GS was ≤6, 3+4, 4+3, ≥8 and 32.8%, 46.3%, 11.5%, and 9.4%, respectively. Significant correlations for GS, such as stratified GS into ≤6, 3+4, 4+3, ≥8 and low or high grade PC with PSA [all p≤0.05, correlations coefficients (rs) 0.19, 0.24, 0.12) were recorded. Moreover PCA3 correlated to GS stratified in low or high grade PC [p=0.054, rs =0.11]. A significant correlation between TV with PSA and PCA3 [both p≤0.001, rs=0.43 and 0.24] was calculated. PCA3's correlation changed when stratifying GS into ≤6, 3+4, 4+3, ≥8 [rs= 0.29 (p≤0.01), 0.22 (p≤0.001), 0.42 (p≤0.02), 0.01 (p=0.99)]. Irrespectively of Gleason grade, PCA3 did neither correlate with primary nor secondary Gleason pattern specific TV, in contrast PSA significantly correlates with primary GPTV (p≤0.004, rs 0.35). CONCLUSIONS This study confirms PCA3's correlation to TV, and demonstrates the impact of high grade cancer. However PCA3 does not correlate to Gleason pattern specific tumour volume. With this, the limited association of this novel diagnostic marker with PCa's aggressiveness was again demonstrated. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e900 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marco Auprich Graz, Austria More articles by this author Sebastian Mannweiler Graz, Austria More articles by this author Felix K.H. Chun Hamburg, Germany More articles by this author Katrin Mayrhofer Graz, Austria More articles by this author Alexander Haese Hamburg, Germany More articles by this author John F. Ward Houston, TX More articles by this author Richard Babaian Houston, TX More articles by this author Karl Pummer Graz, Austria More articles by this author Herbert Augustin Graz, Austria More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...