Programmed regulation of rat offspring adipogenic transcription factor (PPARγ) by maternal nutrition
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE(2015)
摘要
We determined the protein expression of adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPAR gamma) and its co-repressor and co-activator complexes in adipose tissue from the obese offspring of under- and over-nourished dams. Female rats were fed either a high-fat (60% kcal) or control (10% kcal) diet before mating, and throughout pregnancy and lactation (Mat-OB). Additional dams were 50% food-restricted from pregnancy day 10 to term [intrauterine growth-restricted (IUGR)]. Adipose tissue protein expression was analyzed in newborn and adult male offspring. Normal birth weight Mat-OB and low birth weight IUGR newborns had upregulated PPAR gamma with variable changes in co-repressors and co-activators. As obese adults, Mat-OB and IUGR offspring had increased PPAR gamma with decreased co-repressor and increased co-activator expression. Nutritionally programmed increased PPAR gamma expression is associated with altered expression of its co-regulators in the newborn and adult offspring. Functional studies of PPAR gamma co-regulators are necessary to establish their role in PPAR gamma-mediated programmed obesity.
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关键词
co-activator proteins,co-repressor proteins,maternal obesity,maternal undernutrition,peroxisome proliferator-activated receptors
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