Fas, Fas ligand, tolérance immunitaire et cancer : implication dans le cancer du côlon
Bulletin Du Cancer(1998)
摘要
Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.
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关键词
fas ligand,colon,immune tolerance,cancer
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