P37 Changes in daily physical activity in COPD

Background COPD is associated with extrapulmonary manifestations that worsen patient’s daily physical activity (DPA)(1). However, changes in DPA over time and contributing factors in this population have not been established. We hypothesise that patients with COPD would have lower DPA after one year. Method As part of a longitudinal study in COPD (ARCADE), DPA was recorded as the number of steps using a multisensor armband (SenseWear Pro armband) in 28 patients with stable COPD for 7 days and repeated after one year for a further 7 days. Spirometry, body composition, handgrip strength (HGS), six-minute walk distance (6MWD), the COPD assessment test (CAT) were also recorded. Results Patients mean (SD) age was 69 (7) years, BMI 27.2 (4.7) Kg/m 2 and FEV 1 % predicted 52 (15). After one year, there was a reduction in the number of daily steps by 498 (218) steps and fat free mass (FFM) 1.10 (1.75) kg, with an increase in fat mass (FM) 1.06 (2.24) kg and FFM/FM 0.11 (01), all p 1 %, BMI, HGSor 6MWD. The rate of decline in the number of steps was 12.3% per year which related to baseline FFM, r = -0.51 and HGS, r = -0.53, all p Conclusion There was a significant reduction in daily physical activity after one year, which related to baseline FFM and HGS, but was not associated with lung function and 6MWD. Despite maintaining the BMI level, there was a fat free mass turnover, which may indicate a hidden muscle catabolism. Therefore, early management to prevent muscle mass loss would improve patient’s daily physical activity and quality of health. References Watz, K et al (2008) AJRCCM 177(7), pp.743–751.