O-083a Coagulase-negative Staphylococcal Infections In Uk Neonatal Units (nnus)

Background and aims Advances in neonatal intensive care have resulted in improved survival and outcomes of increasingly preterm and very-low-birth-weight (VLBW) neonates. Invasive interventions contribute to higher rates of infections in these infants. This study aims to describe infections with coagulase-negative Staphylococci (CoNS) in UK NNUs participating in a neonatal infection surveillance network (neonIN). Methods neonIN is a web-based surveillance system (www.neonin.org.uk). Details of CoNS cases between January 2010 and May 2014 were extracted. Episodes were considered clinically significant if the infant was treated with at least 5 days of appropriate antibiotics and CRP was >10 mg/L. Repeated growth within 10 days was considered the same episode. Results 440 episodes met the study inclusion criteria (399 infants, 23 NNUs). Incidence was 7.7/1000 NNU-admissions. Baseline characteristics for these episodes are shown in table-1. Resistance data were available for 250/440 (56.8%) episodes with high rates of resistance to flucloxacillin 89.9% (169/188) and penicillin 94.4% (67/71) and moderate resistance to teicoplanin 20.3% (14/69). Susceptibility to vancomycin was high 98.3% (169/172). Conclusions To our knowledge, this is the largest reported cohort of neonatal CoNS infections. Most babies were On behalf of the Neonaotal Infectiion Surveillance Network (neonlN).