The epigenetics of aging and neurodegeneration
Progress in Neurobiology（2015）
摘要
•Epigenetic regulation acts at transcriptional and post-transcriptional levels.•The natural aging process involves widespread epigenetic changes.•Many neurodegenerative diseases are associated with epigenetic dysregulation.•Their reversible nature makes epigenetic alterations promising therapeutic targets.•Methodological obstacles related to epigenetic and brain research are addressed.
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3-mA,3R-tau,3xTg-AD,4PBA,4E-BP,4R-tau,5-caC,5-fC,5-hmC,5-hmU,5-mC,7-mG,A,Aβ,ABCA1,ABCA7,ac,AD,ADAM10,ADAR,ADAT,ADP,AGK2,AICDA,ALKBH5,Alu,ANK1,antagomirs,APOBEC,APOE,APP,APP23 mice,APP/PS1-21 mice,APPind,APPswe,ATP,ATP13A2,BACE,BACE1-AS,BAF,BAG2,BBB,BC200,BDNF,BLCAP,C,C57BL/6 mice,CA,CAG,cAMP,caspase,CBP,CD2AP,CD33,CDK2AP,C. elegans,CHD,CHRM1,CLU,COG3,COX-2,CpG,CR1,CREB,CREBBP,CYFIP2,DAC,DAF-16/FOXO,DG,DNMT,DNMT3L,DP,dsRNA,E1A,E2F1,EC,EDARADD,EID1,EP300,ERK1,eRNA,EZH,f6A,fAD,FANCC,FGF20,FLNA,fPD,FRM-0334,FTO,GABRA2,GAD-3,GADD45,GCF,GCN,GDNF,GFAP,GluR,GPNMB,GR1,GSK-3β,His,H,H2AX,HAT,Hcy,HD,HDAC,HDACI,HdhQ150/Q7 mice,HEK293,HKDM,HKMT,hm6A,HRDM,HSP90,HTT,HuR,I,IBA1,IGF1,IKK,INO,iNPC,iPSC,IRAK1,ISWI,JMJD,K,KAT,Kcnal,L-DOPA,lincRNA,LINE-1,lncRNA,LRRK2,m1A,m1G,m6A,MALAT,MAP2,MAPK,MAPT,MAT,MBD,me,MeCP,MetH,METTL,miR,miRNA,MPP+,MPTP,mRNA,MS4A4E,MS4A6A,MSK,mtDNA,mtDNMT1,MTHF,MTHFR,N171-82Q mice,N2a,NAD,NAT,ncRNA,NDM29,NEAT,NeuN,NF-κB,NFT,NMDA,NPTX,NuRD,p,P300,PAR,PARK16,PASR,P-bodies,PCAF,PcG,PD,PDAPP mice,PGC1-α,PICALM,piRNA,PKCδ,PP2A,PPT,PRC1,PRC2,pre-miRNA,PRMT,PROMPTS,PS,PS1ΔE9,PSD95,PTBP2,Psid-ps1,R,R6/2 mice,RAN,rasiRNA,RISC,RNAi,RNAPII,RNAPIII,ROS,rRNA,S,S100A2,sAD,SAH,SAHA,SAHF,SAHH,SAM,SAMP8,SAT-α,SB,scaRNA,sdRNA,SETDB1,SHMT,shRNA,siRNA,SIRT,smRNA,SNCA,sncRNA,snRNA,snoRNA,SNP,SORBS3,SP,sPD,spliRNA,SPT,ss-siRNA,STX1B,SUV39H,SWI/SNF,T,TACE,TE,TET,Tg19959 mice,Tg2576 mice,THF,TIP60,tiRNA,TNF-α,TNKS2,TOM1L,TREM2,TRF1,tRNA,TSA,TSSa-RNA,U,UCHL1,UTR,VPA,WTAP,Y,YTHDF
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