Developmental exposure to manganese induces lasting motor and cognitive impairment in rats

Tanara V. Peres,Helena Eyng,Samantha C. Lopes,Dirleise Colle,Filipe M. Gonçalves,Débora K.R. Venske,Mark W. Lopes,Juliana Ben,Julia Bornhorst,Tanja Schwerdtle,Michael Aschner,Marcelo Farina,Rui D. Prediger,Rodrigo B. Leal

NeuroToxicology（2015）

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摘要

•Immature rats received i.p. injections of MnCl2 for 5 days in a critical period of brain development.•In adulthood, rats submitted to behavioral tasks displayed motor and short-term memory deficits.•GFAP content was increased in the striatum on PND70.•Hippocampal and striatal antioxidant parameters were altered.•Oxidative stress may contribute to Mn-induced developmental neurotoxicity.

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关键词

CNS,ICP-MS,i.p.,GFAP,GR,GSH,GSSG,GPx,MAPKs,NPSH,PND,NADPH

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