Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

Adrien Decque,Olivier Joffre,Joao G Magalhaes,Jack-Christophe Cossec,Ronnie Blecher-Gonen,Pierre Lapaquette,Aymeric Silvin,Nicolas Manel,Pierre-Emmanuel Joubert,Jacob-Sebastian Seeler,Matthew L Albert,Ido Amit,Sebastian Amigorena,Anne Dejean

NATURE IMMUNOLOGY（2015）

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摘要

Sumolyation regulates wide-ranging biological processes, but its influence on innate immunity is unclear. Amigorena and colleagues show that sumoylation negatively regulates interferon-β expression and anti-viral immunity.

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nature,immunology

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