T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
NATURE IMMUNOLOGY(2015)
摘要
To date, structural analysis has demonstrated a highly consistent binding pattern of the TCR to the MHC molecule. Rossjohn and colleagues reveal the first structures of two human T reg cell TCRs and show that they bind with a reversed polarity to the MHC.
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关键词
antigen processing and presentation,x ray crystallography
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