Production and characterisation of recombinant human chaperonin 10 for treatment of inflammatory disease

Dean Jason Naylor, Ben Hunt,Angelo Guidolin,Allan W Hey,Stan Bastiras,Christopher J De Bakker,David Y Chin,Christopher P Marquis,Daniel Lambert,Christopher B Howard,Caroline A Dobbin,Stephen M Mahler

Process Biochemistry（2015）

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摘要

•Production of a novel protein based therapeutic for treating inflammatory diseases.•Process productivity improved using specific host strain and gene promoter elements.•Partial codon optimisation of Cpn10 gene reduced molecular variants.

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关键词

Cpn10,Endotoxin,Immunomodulator,Inflammation,RAMPs,Systemic Lupus Erythematosus (SLE)

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