New glycosylated conjugate copolymer N-acetyl-β-d-glucosaminyl-pluronic: Synthesis, self-assembly and biological assays

Tiago Elias Allievi Frizon,Yasmine Miguel Serafini Micheletto,José Luiz Westrup, Priscila Sayoko Silva Wakabayashi, Francieli Rocha Serafim,Adriani Paganini Damiani,Luiza Martins Longaretti,Vanessa Moraes de Andrade,Fernando Carlos Giacomelli,Sébastien Fort,Alexandre Gonçalves Dal Bó

Colloids and Surfaces B: Biointerfaces（2015）

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摘要

•Novel glycosylated copolymer conjugate was successfully synthesized via click chemistry.•8.7nm diameter carbohydrate decorated micelles were produced.•The micelles demonstrated colloidal stability.•The produced nanostructures are neither cytotoxic nor genotoxic.•The assemblies have potential application as site-directed drug delivery system.

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关键词

Amphiphilic glycoconjugates,Click chemistry,Self-assembled micelles

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