Abstract 6248: The Direct Renin Inhibitor, Aliskiren, Improves Cardiac Function Via Direct Renin Inhibition And Via Renin Receptor Modulation In A Rodent Model Of Diabetic diastolic heart failure.

Kim A Connelly,Darren J Kelly,Sandra Kim,Michael Zhang,Kerri Thai,Andrew Advani,Henry Krum,Richard E Gilbert

Circulation（2008）

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摘要

Background: Heart failure, a common cause of morbidity and mortality in diabetic patients, is traditionally treated by ACE inhibitors and ARBs, agents that block the renin-angiotensin system (RAS)....

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