Abstract 13411: p90RSK Inhibits C Terminus of Hsc70-interacting Protein (CHIP) Ubiquitin E3 Ligase Activity and Promotes Cardiac Apoptosis Through ERK5-Ser 496 Phosphorylation and Association

Nhat Tu Le,Yuichiro Takei,Tetsuro Shishido,Chang-Hoon Woo,Yan Lu,Carolyn McClain,Chen Yan,Cam Patterson,Jay Yang,Jun Ichi Abe

Circulation（2011）

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摘要

Rationale: Cardiac dysfunction is accelerated in DM patients after MI. Previously, we reported the critical role of ERK5 and CHIP association on CHIP Ub E3 ligase activity, which inhibits inducible...

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