Abstract 17571: Prognostic Role of Soluble Micrornas in the Early Detection of High Platelet Reactivity and Periprocedural Myocardial Damage in Patients Undergoing Percutaneous Coronary Intervention

Introduction: Despite an optimal antiplatelet strategy, high residual platelet reactivity (HRPR) is associated with an increased risk of procedural myocardial infarction (PMI) in patients undergoing percutaneous coronary intervention (PCI). MicroRNAs (miR), small non-coding RNA molecules, play a significant role in vascular and platelet pathways by modulating several transcription factors. However, nowadays, few clinical studies has been conducted to evaluate the prognostic role of microRNAs in patients undergoing PCI. Hypothesis: Thus, we aimed to analyze possible role of these molecules on platelet aggregation and PMI development in such patients. Methods: To-date we enrolled 23 patients. Blood samples were collected for detection of cardiac markers (troponin I and creatine kinase-MB) and microRNAs extraction. RT-quantitative PCR was performed and relative quantification of miR expression calculated with the 2-ΔΔCt method. Platelet reactivity was measured by the VerifyNow P2Y12 assay and HRPR was define...