Abstract 21191: Disturbed Flow-Mediated Reactive Oxygen Species Production and Subsequent Protein Kinase C{zeta} Activation Plays a Key Role in Endothelial Apoptosis via PIASy (SUMO E3 ligase)-Mediated p53-SUMOylation and p53 Protein Stability

Kyungsun Heo,Hakjoo Lee,Patrizia Nigro,Nhattu Le,Eugene Chang,Carolyn Mcclain,Bradford C Berk,Keigi Fujiwara,Changhoon Woo,Junichi Abe

Circulation（2010）

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摘要

Atherosclerosis formation is readily observed in certain areas of the arterial tree such as branch points, which experience disturbed flow (d-flow). A positive correlation between protein kinase C ...

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关键词

Apoptosis,Endothelial function,Protein kinase C,Signal transduction,Aorta

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