Abstract 18468: Serum Hepcidin Predicts New Onset Heart Failure in Women in the Community

Introduction: Iron status and iron-regulatory hormone hepcidin have found to be associated with cardiovascular disease and established heart failure (HF). However, their role in the development of new onset HF in currently unknown. This study sought to investigate the association of iron status and hepcidin levels with new onset HF in the community. Methods: In 6471 subjects from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND), a prospective, community-based, cohort study, we analyzed the association between serum hepcidin, parameters of iron status (ferritin, transferrin saturation) and the risk for new onset HF. Results: Mean age was 53±12 years and 49.3% were male. Median hepcidin concentration was 3.06 (1.67-4.97) nM, median ferritin level was 97 (48-172) ug/L and mean transferrin saturation was 24.8±9.4% (all lower in women; all P<0.001). During a median follow-up of 8.3 years [IQR 7.8-8.9], 203 subjects (3.1%) were newly diagnosed with HF. Per increasing hepcidin or ferritin quintil...