Abstract P295: Oxidative Stress Biomarkers and Incidence of Post-Operative Atrial Fibrillation in the OPERA Trial

Background: Post-operative atrial fibrillation (PoAF) commonly complicates cardiac surgery. Animal studies point to oxidative stress as a key mechanism triggering PoAF, and yet, the extent to which oxidative stress might relate to PoAF risk in humans remains speculative. Methods and Results: We assessed the association of validated oxidative stress biomarkers (F2-Isoprostanes, F2-IsoP, Isofurans, IsoF, and F3-Isoprostanes, F3-IsoP) in plasma and urine, with incident PoAF among 551 cardiac surgery patients. Biomarkers were measured using standardized methods at baseline, the end of surgery, and post-op day 2. PoAF lasting ≥ 30seconds was confirmed by rhythm strip or ECG, and centrally adjudicated. Outcomes were assessed until hospital discharge or post-operative day 10, whichever occurred first. Urine level of each oxidative stress biomarkers demonstrated a rise at the end of surgery (2-3 fold over baseline, Pu003c0.001), which subsequently fell and were comparable to baseline by post-op day 2. In contrast, pl...