Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Felix R Day,Katherine S Ruth,Deborah J Thompson,Kathryn L Lunetta,Natalia Pervjakova,Daniel I Chasman,Lisette Stolk,Hilary K Finucane,Patrick Sulem,Brendan Bulik-Sullivan,Tõnu Esko,Andrew D Johnson,Cathy E Elks,Nora Franceschini,Chunyan He,Elisabeth Altmaier,Jennifer A Brody,Lude L Franke,Jennifer E Huffman,Margaux F Keller,Patrick F McArdle,Teresa Nutile,Eleonora Porcu,Antonietta Robino,Lynda M Rose,Ursula M Schick,Jennifer A Smith,Alexander Teumer,Michela Traglia,Dragana Vuckovic,Jie Yao,Wei Zhao,Eva Albrecht,Najaf Amin,Tanguy Corre,Jouke-Jan Hottenga,Massimo Mangino,Albert V Smith,Toshiko Tanaka,Gonçalo R Abecasis,Irene L Andrulis,Hoda Anton-Culver,Antonis C Antoniou,Volker Arndt,Alice M Arnold,Caterina Barbieri,Matthias W Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Leslie Bernstein,Suzette J Bielinski,Carl Blomqvist,Eric Boerwinkle,Natalia V Bogdanova,Stig E Bojesen,Manjeet K Bolla,Anne-Lise Borresen-Dale,Thibaud S Boutin,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Archie Campbell,Harry Campbell,Stephen J Chanock,J Ross Chapman,Yii-Der Ida Chen,Georgia Chenevix-Trench,Fergus J Couch,Andrea D Coviello,Angela Cox,Kamila Czene,Hatef Darabi,Immaculata De Vivo,Ellen W Demerath,Joe Dennis,Peter Devilee,Thilo Dörk,Isabel dos-Santos-Silva,Alison M Dunning,John D Eicher,Peter A Fasching,Jessica D Faul,Jonine Figueroa,Dieter Flesch-Janys,Ilaria Gandin,Melissa E Garcia,Montserrat García-Closas,Graham G Giles,Giorgia G Girotto,Mark S Goldberg,Anna González-Neira,Mark O Goodarzi,Megan L Grove,Daniel F Gudbjartsson,Pascal Guénel,Xiuqing Guo,Christopher A Haiman,Per Hall,Ute Hamann,Brian E Henderson,Lynne J Hocking,Albert Hofman,Georg Homuth,Maartje J Hooning,John L Hopper,Frank B Hu,Jinyan Huang,Keith Humphreys,David J Hunter,Anna Jakubowska,Samuel E Jones,Maria Kabisch,David Karasik, Julia A Knight,Ivana Kolcic,Charles Kooperberg,Veli-Matti Kosma,Jennifer Kriebel,Vessela Kristensen,Diether Lambrechts,Claudia Langenberg,Jingmei Li,Xin Li,Sara Lindström,Yongmei Liu,Jian'an Luan,Jan Lubinski,Reedik Mägi,Arto Mannermaa,Judith Manz,Sara Margolin,Jonathan Marten,Nicholas G Martin,Corrado Masciullo,Alfons Meindl,Kyriaki Michailidou,Evelin Mihailov,Lili Milani,Roger L Milne,Martina Müller-Nurasyid,Michael Nalls,Benjamin M Neale,Heli Nevanlinna,Patrick Neven,Anne B Newman,Børge G Nordestgaard,Janet E Olson,Sandosh Padmanabhan,Paolo Peterlongo,Ulrike Peters,Astrid Petersmann,Julian Peto,Paul D P Pharoah,Nicola N Pirastu,Ailith Pirie,Giorgio Pistis,Ozren Polasek,David Porteous,Bruce M Psaty,Katri Pylkäs,Paolo Radice,Leslie J Raffel,Fernando Rivadeneira,Igor Rudan,Anja Rudolph,Daniela Ruggiero,Cinzia F Sala,Serena Sanna,Elinor J Sawyer,David Schlessinger,Marjanka K Schmidt,Frank Schmidt,Rita K Schmutzler,Minouk J Schoemaker,Robert A Scott,Caroline M Seynaeve,Jacques Simard,Rossella Sorice,Melissa C Southey,Doris Stöckl,Konstantin Strauch,Anthony Swerdlow,Kent D Taylor,Unnur Thorsteinsdottir,Amanda E Toland,Ian Tomlinson,Thérèse Truong,Laufey Tryggvadottir,Stephen T Turner,Diego Vozzi,Qin Wang,Melissa Wellons,Gonneke Willemsen, James F Wilson,Robert Winqvist,Bruce B H R Wolffenbuttel,Alan F Wright,Drakoulis Yannoukakos,Tatijana Zemunik,Wei Zheng,Marek Zygmunt,Sven Bergmann,Dorret I Boomsma,Julie E Buring,Luigi Ferrucci,Grant W Montgomery,Vilmundur Gudnason,Tim D Spector,Cornelia M van Duijn,Behrooz Z Alizadeh,Marina Ciullo,Laura Crisponi,Douglas F Easton,Paolo P Gasparini,Christian Gieger,Tamara B Harris,Caroline Hayward,Sharon L R Kardia,Peter Kraft,Barbara McKnight,Andres Metspalu,Alanna C Morrison,Alex P Reiner,Paul M Ridker,Jerome I Rotter,Daniela Toniolo,André G Uitterlinden,Sheila Ulivi,Henry Völzke,Nicholas J Wareham,David R Weir,Laura M Yerges-Armstrong,Alkes L Price,Kari Stefansson,Jenny A Visser,Ken K Ong,Jenny Chang-Claude,Joanne M Murabito,John R B Perry,Anna Murray
NATURE GENETICS（2015）
引用 396|浏览303
摘要
John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.
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关键词
genome wide association studies,breast cancer
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