P925: Somatosensory evoked potential (SEP) modulation by quadripulse transcranial magnetic stimulation (QPS) in benign myoclonus epilepsy patients

•In healthy subjects, quadripulse transcranial magnetic stimulation (QPS) over the primary motor cortex (M1) induces bidirectional heterotopic plasticity in the somatosensory cortex (S1), following the Bienenstock–Cooper–Munro (BCM)-like theory.•In patients with benign myoclonus epilepsy (ME patients), QPS over M1 induces long-term potentiation (LTP) but no long-term depression (LTD) in S1.•QPS is not applicable to the treatment for ME patients because the frequency dependency may be completely different between the healthy subjects and the patients.