Expectancy of asthma phenotype having different polymorphism of PSMA6, PSMC6, PSMA3 proteasomal genes: Lithuanian study

Background According to the scientific literature, proteasomes and proteasomal genes which encode them may be important in development of different chronic inflammatory diseases, including asthma, through the activation of the NFB protein. We aimed to investigate expectancy of asthma in subjects with different polymorphism of proteasomal genes PSMA6 (rs1048990 and rs2277460), PSMC6 (rs2295827 and rs2295827) and PSMA3 (rs2348071) and to analyze possible relation to gender, allergic status and lung function.