Prognostic value of health-related quality of life for overall survival in elderly non-small-cell lung cancer patients

•We investigated whether the health-related quality of life score is a prognostic factor for overall survival (OS) in elderly patients with advanced NSCLC.•Global health status (GH) dimension score at baseline was associated with favourable OS when adjusted for clinical, functional, and histological factors.•We distinguished three groups according to GH score: high (GH <46), intermediate (46 ≤GH ≤67), and low (GH >67) mortality risk.•Subgroup analyses suggested the baseline GH score to be a predictor of treatment effect.