Polyphenol-rich propolis extracts from China and Brazil exert anti-inflammatory effects by modulating ubiquitination of TRAF6 during the activation of NF-κB

Kai Wang,Lin Hu,Xiaolu Jin,Quanxin Ma,Maria Cristina Marcucci, Amandio Augusto Lagareiro Netto,Alexandra Christine Helena Frankland Sawaya,Shuai Huang,Wenkai Ren,Michael Conlon,David L Topping,Fuliang Hu

Journal of Functional Foods（2015）

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摘要

•Polyphenol profiles of Chinese/Brazilian propolis are different.•Brazilian/Chinese propolis showed some bioequivalence in different inflammatory models.•Anti-inflammatory effects by propolis occurred through blunting NF-κB.•Propolis suppressed NF-κB activation via inhibiting the ubiquitination of TRAF6.

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关键词

Propolis,Polyphenols,Anti-inflammatory,LPS,TRAF6,NF-κB

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