Chitooligosaccharides from the shrimp chitosan hydrolysate induces differentiation of murine RAW264.7 macrophages into dendritic-like cells
Journal of Functional Foods(2015)
摘要
•Oligomixture and LMWC with different Mw were isolated from chitosan hydrolysate.•Both LMWC and oligomixture inhibited the superoxide production in RAW264.7 cells.•Oligomixture, but not LMWC, induced DC-like morphological changes in RAW264.7 cells.•Oligomixture induced G0/G1 phase cell cycle arrest in RAW264.7 cells.•Oligomixture promoted the expression of mature DC-associated cell markers.
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关键词
Chitosan,Chitooligosaccharide,Dendritic cell,RAW264.7 macrophage,Differentiation,Immune-modulation
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