Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

Jungeun Kim,C Chae,Gicheon Kim,Won Hwang,Jisun Hwang,Sungmin Hwang,Young Kim,Youngtae Ahn,Sunggyoo Park,Changduk Jun,Dipayan Rudra,Sinhyeog Im

Journal of Functional Foods（2015）

引用 36|浏览43

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摘要

•Determination of a selection criterion to identify anti-inflammatory probiotics.•Validation of anti-inflammatory property using experimental rheumatoid arthritis (RA).•L. helveticus suppressed development and progression of RA.•L. helveticus reduced pro-inflammatory cytokines but increased IL-10 levels.•CD11c+ dendritic cells mediated phenotypic changes induced by L. helveticus.

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关键词

RA,CIA,L. helveticus,Th,IL,TNF-α,IFN-γ,dLN,mLN,DC,PMA

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