STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES

Chialing Chen,Ili Chen,Jihjung Chen,Dauchang Wei, Hanjie Hsieh,Kenming Chang,Cherngchyi Tzeng,Taichi Wang

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY（2015）

引用 3|浏览17

暂无评分

摘要

Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.

查看译文

关键词

N-Alkylation,O-Alkylation,Quinolin-2(1H)-one

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要