Allergic Diseases in Upper Respiratory Tract

Three allergic disorders manifested on the nose were reported in this session. First of all, an immediate type (Type I) allergy was examplified by the so-called nasal allergy of Dermatophagoides farinae. In addition to the expression of their clinical picture, effectiveness of the hyposensitization therapy was precisely described, including changes of nasal provocation threshold, PK titer, blocking antibody titer, IgE and IgE antibody value during the period of the therapy. Secondarily, it was speculated that Arthus reaction (Type III) induced by the bacterial infection to the paranasal sinuses was one of the main factors producing chronic sinusitis. This theory was mainly proved by immunohistological examination which showed that antibodies to Staphylococcus aureus or complements were distributed in the infiltrated cells, perivascular regions, basement membrane so on. On the third, clinical pictures and differentiation of Wegener's Granulomatosis (WG) and malignant granuloma of the nose (MGN) were presented. It was concluded that the both were clearly different, since, from immunological and histological findings, WG has characteristics of autoimmune disease and MGN could be classified in malignant lymphoma.