Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians

Csilla Sipeky,Agnes Weber,Bela I. Melegh,Petra Matyas,Ingrid Janicsek,Renata Szalai,Istvan Szabo,Reka Varnai,Greta Tarlos,Alma Ganczer,Bela Melegh

Environmental Toxicology and Pharmacology（2015）

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摘要

•First study on functional CYP4F2 (V433M) SNP in Roma and Hungarian populations.•Marginal interethnic differences of CYP4F2*3 missense variant could be revealed.•This allele is more common in Roma (0.32) than in Hungarian's (0.23).•Roma carrier frequency (53.5%) suggest the need for higher daily mean warfarin dose.•Roma have elevated probability for under-anticoagulation in long-term warfarin use.

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关键词

CYP4F2*3 (rs2108622, V433M),Population pharmacogenetics,Roma,Hungarian

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