Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation

Meng Mei,Futian Tang,Meili Lu,Xin He, Hongxin Wang,Xuwei Hou,Jin Hu,Chonghua Xu,Ronghui Han

Environmental Toxicology and Pharmacology（2015）

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摘要

•Astragaloside IV (ASIV) inhibits the apoptosis of hypertrophic cardiomyocyte induced by ISO.•ASIV ameliorates mitochondria dysfunction in heart tissue and cell induced by ISO.•ASIV reduces oxidative stress induced by ISO.•ASIV down-regulates calpain-1 expression and activity.

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关键词

Calpain-1,Oxidation,Apoptosis,Hypertrophy,Astragaloside IV

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