Convergent Synthesis of Polynitrile and/or Polyamine Dendrimers through Hydroaminomethylation and Michael Addition

A general concept for a versatile convergent synthesis of polynitrile and/or polyamine dendrimers has been developed by applying Vogtle's procedure in combination with the tandem hydroformylation/reductive amination sequence, known as hydroaminomethylation. In this approach, first Vogtle's procedure is used to generate the desired dendron, which can then be attached to different types of polyfunctionalized cores (e. g., polyamine, polyhalide, or polyolefin cores) to provide the desired globular architecture. This method can be used as a general procedure for the synthesis of dendrimers with designed shell and core properties as shown by the examples presented.