STUDY OF ELEMENTAL CONCENTRATION AND DISTRIBUTION IN HUMAN FEMORAL HEAD BY PIXE AND SRXRF

In order to explore the distribution and the loss way of inorganic substances in bone and to provide scientific basis for prevention and therapy of osteoporosis, Proton Induced X-ray Emission (PIXE) method is used for the determination of elemental concentration in femoral head from five autopsies and seven patients with femoral neck broken, and Synchrotron Radiation X-ray Fluorescence (SRXRF) microprobe analysis technique is used to scan a slice of the femoral head from its periphery to its center, via cartilage, compact and spongy zones. The results show that the concentrations of P , Ca , Fe , Cu , Sr in a control group are higher than those in a patient group, but the concentrations of S , K , Zn , Mn are not significantly different. The quantitative computerized tomography of elemental distribution, such as Ca , P , K , Fe , Zn , Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, is investigated. Combined with the correlations between P , K , Zn , Sr and Ca , the loss way of minerals and the physiological functions of some metal elements in bone are also discussed.