Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5- a ][1,3,5]triazin-5-amines

An efficient and practical procedure for the synthesis of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines was developed and their antiproliferative activity against cancer cells and anti-angiogenic activity were explored.