Regioselective Synthesis Of Azabicycloadducts Derived From Benzo[B]Thiophene-2,3-Dione And Pipecolinic Acid

A simple and efficient method for the synthesis of novel spiropyrrolidines has been accomplished by regioselective 1, 3-dipolar cycloaddition reactions of azomethine ylide generated by benzo[b]thiophene-2,3-dione and piperidine 2-carboxylic acid in good yield. Molecular orbital calculations have been performed to investigate the regioselectivity of the cycloaddition process.