Development and validation a LC–MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study

Meizhen Li,Fang Tang,Feifan Xie,Yisha Lv,Peng Yu,Zhi Liu,Zeneng Cheng

Journal of Chromatography B（2015）

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摘要

•Simultaneous determination of agomelatine and its metabolites in human plasma by LC–MS/MS.•Simple protein precipitation procedure was employed.•Wide linear ranges for the target analytes were obtained.•Successfully applied to a bioequivalence study in healthy Chinese volunteers.

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关键词

LC–MS/MS,Agomelatine,7-Desmethyl-agomelatine,3-Hydroxy-agomelatine,Metabolite,Plasma,Bioequivalence

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