Development and validation of an improved HPLC-MS/MS method for comparative pharmacokinetics of penehyclidine hydrochloride following a single intravenous or intramuscular injection

Libo Zhao,Yannan Zang,Yuwen Sun,Zhongna Wei,Shan Jing,Qian Wang,Youzhong An,Yi Fang,Wanyu Feng

Journal of Chromatography B（2015）

引用 3|浏览32

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摘要

•Developing an improved HPLC-MS/MS method to determine PHC in human plasma/urine.•PHC was well tolerate via i.v. or i.m. administration routes.•PHC was nearly absorbed completely via the i.m. administration route.•The two administration routes of PHC are interchangeable in clinical practice.

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关键词

Penehyclidine hydrochloride (PHC),Comparative pharmacokinetics,Bioavailability,Intramuscular injection (i.m.),Intravenous injection (i.v.)

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