What Are the Most Important New Targets in Breast Cancer?

Breast cancer is a remarkably heterogeneous disease. Data clearly demonstrate the presence of multiple molecular subtypes of breast cancer, and alterations in cell physiology shared by most tumors have been identified. These recent developments in our understanding of the molecular events involved in breast cancer have led to the identification of novel targets as well as anticancer therapies based on these targets. These therapies are referred to as targeted therapy in that the agent has a high specificity for molecules involved in molecular events responsible for the cancer phenotype. This review highlights some of the most promising future targets in breast cancer.