Transition metal complexes of 3-acetylpyridine 4 N-(2-pyridyl)thiosemicarbazone (HAPS); structural, spectroscopic, and biological studies

This work examines transition metal ion complexes which have been synthesized from 3-acetylpyridine N-4-(2-pyridyl)thiosemicarbazone (HAPS) (1). [Cu(HAPS)(2)Cl-2] center dot H2O (2), [Hg(HAPS)(2)Cl-2] (3), [Ni(HAPS)Cl-2] center dot 2H(2)O (4), [UO2(APS)(2)] center dot 2H(2)O (5), [VO(HAPS)(2)]SO4 center dot H2O (6), and [Zn(HAPS)(2)Cl-2] (7) were characterized by elemental analysis, spectral (IR, H-1-NMR, and UV-Vis), magnetic, and molar conductance measurements. The biochemical studies showed that 2 and 3 have powerful and complete degradation on both DNA and protein. Complexes 2, 4, and 7 showed significant antioxidant properties, especially scavenging on superoxide and hydroxyl radicals. The antibacterial screening demonstrated that all studied complexes have maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.