Granulocyte colony-stimulating factor attenuates spinal cord injury-induced mechanical allodynia in adult rats

Kei Kato,Masao Koda,Hiroshi Takahashi,Tsuyoshi Sakuma,Taigo Inada,Koshiro Kamiya,Mitsutoshi Ota,Satoshi Maki,Akihiko Okawa,Kazuhisa Takahashi,Masashi Yamazaki,Masaaki Aramomi,Masayuki Hashimoto,Osamu Ikeda,Chikato Mannoji,Takeo Furuya

Journal of the Neurological Sciences（2015）

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摘要

Spinal cord injury (SCI) can cause neuropathic pain (NeP), often reducing a patient's quality of life. We recently reported that granulocyte colony-stimulating factor (G-CSF) could attenuate NeP in several SCI patients. However, the mechanism of action underlying G-CSF-mediated attenuation of SCI-NeP remains to be elucidated.

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关键词

Spinal cord injury,Neuropathic pain,G-CSF,Allodynia,Inflammatory cytokine,Central pain

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